Johnston H M, Morris B J
Department of Pharmacology, University of Glasgow, UK.
Brain Res Mol Brain Res. 1994 Aug;25(1-2):147-50. doi: 10.1016/0169-328x(94)90291-7.
The increased levels of proenkephalin mRNA in the dentate gyrus following hippocampal stimulation have been assumed to be a consequence of the transient induction of c-fos. Injection of 50 microM NMDA in vivo onto the dendrites of a small number of granule cells causes a pronounced but highly localised elevation in proenkephalin mRNA levels 24 h later, whereas vehicle has no effect. In contrast, there is a widespread induction of c-fos mRNA throughout the dentate gyrus, 45 min after injection of either vehicle or NMDA, suggesting that induction of c-fos expression is unrelated to the subsequent, anatomically discrete, increase in proenkephalin mRNA levels.
海马体刺激后齿状回中前脑啡肽原mRNA水平升高，被认为是c-fos瞬时诱导的结果。在体内向少量颗粒细胞的树突注射50微摩尔的N-甲基-D-天冬氨酸（NMDA），24小时后会导致前脑啡肽原mRNA水平显著但高度局部性的升高，而注射赋形剂则无此效果。相比之下，在注射赋形剂或NMDA后45分钟，整个齿状回中c-fos mRNA会广泛诱导，这表明c-fos表达的诱导与随后前脑啡肽原mRNA水平在解剖学上离散的增加无关。
