Futoryan T, Gilchrest B A
Department of Dermatology, Boston University School of Medicine, MA 02118.
Nutr Rev. 1994 Sep;52(9):299-310. doi: 10.1111/j.1753-4887.1994.tb01461.x.
Retinoids are a group of naturally occurring and synthetic compounds with vitamin A-like biological activity. They play an important role in vision, reproduction, growth, and epithelial cell differentiation. Recent discoveries of specific retinoid cellular binding proteins and nuclear receptors have led to a better (although not complete) understanding of the complex mechanisms of retinoid action. Numerous clinical studies have demonstrated beneficial effects of retinoids on skin diseases such as acne, psoriasis, ichthyoses, keratodermas, skin cancers and their precursors, as well as a reversal of the effects of photoaging.
类视黄醇是一类具有维生素A样生物活性的天然存在和合成的化合物。它们在视觉、生殖、生长和上皮细胞分化中发挥重要作用。最近对特定类视黄醇细胞结合蛋白和核受体的发现，使人们对类视黄醇作用的复杂机制有了更好（尽管不完整）的理解。大量临床研究表明，类视黄醇对痤疮、银屑病、鱼鳞病、角化皮肤病、皮肤癌及其癌前病变等皮肤疾病具有有益作用，还能逆转光老化的影响。
