Khalil Samar, Bardawil Tara, Stephan Carla, Darwiche Nadine, Abbas Ossama, Kibbi Abdul Ghani, Nemer Georges, Kurban Mazen
a Department of Internal Medicine , American University of Beirut , Beirut , Lebanon.
b Department of Dermatology , American University of Beirut , Beirut , Lebanon.
J Dermatolog Treat. 2017 Dec;28(8):684-696. doi: 10.1080/09546634.2017.1309349. Epub 2017 Apr 2.
Retinoids are a class of compounds derived from vitamin A or having structural and/or functional similarities with vitamin A. They are classified into three generations based on their molecular structures. Inside the body, retinoids bind to several classes of proteins including retinoid-binding proteins and retinoid nuclear receptors. This eventually leads to the activation of specific regulatory regions of DNA - called the retinoic acid response elements - involved in regulating cell growth, differentiation and apoptosis. Several clinical trials have studied the role of topical and systemic retinoids in disease, and research is still ongoing. Currently, retinoids are used in several fields of medicine. This paper aims to review the structure, mechanisms of action, and adverse effects of retinoids, as well as some of their current uses in Dermatology.
类视黄醇是一类源自维生素A或与维生素A具有结构和/或功能相似性的化合物。根据其分子结构，它们被分为三代。在体内，类视黄醇与几类蛋白质结合，包括类视黄醇结合蛋白和类视黄醇核受体。这最终导致DNA特定调控区域（称为视黄酸反应元件）的激活，这些区域参与调节细胞生长、分化和凋亡。多项临床试验研究了局部和全身使用类视黄醇在疾病中的作用，相关研究仍在进行中。目前，类视黄醇在医学的多个领域都有应用。本文旨在综述类视黄醇的结构、作用机制、不良反应以及它们目前在皮肤科的一些应用。
