Goncharova S I, Poddubnyĭ A F, Panasiukova O R
Probl Tuberk. 1993(2):30-2.
Characteristic features of the clinical course and immune status were studied in 24 histiocytosis X patients. Immunologic studies were carried out in 15 histiocytosis X patients by the methods that characterize the T- and B-lymphocyte systems, their sensitivity to tuberculin, the receptor apparatus of lymphocytes and neutrophilic granulocytes and autoimmune processes. The immune status of these patients is distinguished by disorders caused by secondary cellular deficit combined with the imbalance of the immunoregulatory cell system. Disorders of the B-cell link of the immune system are less pronounced and there is a drop in the production of natural antibodies and IgM. A high degree of sensitization to tuberculin was detected in the in vivo and in vitro tests, which indirectly testifies to the tuberculous origin of histiocytosis X.
对24例组织细胞增多症X患者的临床病程和免疫状态的特征进行了研究。通过表征T淋巴细胞和B淋巴细胞系统、它们对结核菌素的敏感性、淋巴细胞和嗜中性粒细胞的受体装置以及自身免疫过程的方法，对15例组织细胞增多症X患者进行了免疫学研究。这些患者的免疫状态的特征是由继发性细胞缺陷引起的紊乱以及免疫调节细胞系统的失衡。免疫系统B细胞环节的紊乱不太明显，天然抗体和IgM的产生有所下降。在体内和体外试验中均检测到对结核菌素的高度敏感性，这间接证明了组织细胞增多症X的结核起源。
