Padovani M, Tillie-Leblond I, Wallaert B
Service de pneumologie et immuno-allergologie, hôpital Calmette, CHRU, Lille.
Rev Prat. 1994 Oct 1;44(15):2055-8.
No single laboratory examination is diagnostic. On the other hand, such examinations support the diagnosis and aid in management of treated patients. In the serum, there is lymphopenia with a lowered CD4/CD8 ratio. An increase in beta 2-microglobulin and in the soluble IL-2 receptor reflect T lymphocyte activation. A classic observation is hypercalcaemia with hypercalciuria. The increase in angiotensin I converting enzyme reflects the body granulomatous mass. The results of bronchoalveolar lavage show the characteristics of the alveolitis associated with granulomatosis, accumulation of CD4+ T lymphocytes and activated alveolar macrophages. In practice, biochemical anomalies are of interest in the follow-up of treated patients.
没有单一的实验室检查具有诊断性。另一方面，这些检查有助于诊断并辅助已治疗患者的管理。血清中存在淋巴细胞减少且CD4/CD8比值降低。β2-微球蛋白和可溶性白细胞介素-2受体增加反映T淋巴细胞活化。一个典型表现是高钙血症伴高钙尿症。血管紧张素I转换酶增加反映机体肉芽肿量。支气管肺泡灌洗结果显示与肉芽肿病相关的肺泡炎特征、CD4+T淋巴细胞积聚和活化的肺泡巨噬细胞。实际上，生化异常对已治疗患者的随访有意义。
