Bergoin C, Lamblin C, Wallaert B
Service de Pneumologie et Immuno-Allergologie, Hôpital A.-Calmette, CHRU, 59037 Lille Cedex.
Ann Med Interne (Paris). 2001 Feb;152(1):34-8.
Sarcoidosis is a multisystem granulomatous disease of unknown origin. No single biological marker allows definitive diagnosis of sarcoidosis or may accurately predict the disease prognosis. However, some biological markers are helpful tools as diagnostic aids and disease activity markers. At the blood level, lymphopenia with CD4 depletion, elevated levels of serum-angiotensin converting enzyme, lyzozyme, beta 2 microglobulin and disturbed calcium metabolism resulting in hypercalcemia and hypercalciuria can help guide diagnosis. Lymphocytic alveolitis with a high CD4/CD8 ratio in bronchoalveolar lavage fluid is highly suggestive of the disease. A wide range of new biological markers are proposed but their pronostic significance is still controversial. In clinical practice, biological markers may help in monitoring treated patients with sarcoidisis.
结节病是一种病因不明的多系统肉芽肿性疾病。没有单一的生物标志物能够确诊结节病，也无法准确预测疾病的预后。然而，一些生物标志物作为诊断辅助手段和疾病活动标志物是有用的工具。在血液层面，伴有CD4细胞减少的淋巴细胞减少、血清血管紧张素转换酶、溶菌酶、β2微球蛋白水平升高以及导致高钙血症和高钙尿症的钙代谢紊乱有助于指导诊断。支气管肺泡灌洗液中CD4/CD8比值高的淋巴细胞性肺泡炎高度提示该病。人们提出了多种新的生物标志物，但其预后意义仍存在争议。在临床实践中，生物标志物可能有助于监测结节病患者的治疗情况。
