[钙拮抗剂和β-肾上腺素能阻滞剂对十二指肠消化性溃疡患者胃功能紊乱的影响]

[The effect of calcium antagonists and beta-adrenoblockaders on disordered stomach functions in patients with duodenal peptic ulcer].

作者信息

Tsimmerman Ia S, Budnik Iu B, Syman L N

出版信息

Ter Arkh. 1994;66(8):47-52.

Abstract

The effect of a single dose of nifedipine or propranolol hydrochloride on gastric acid production and motility has been assessed in 90 duodenal ulcer (DU) patients having the relapse. Intragastric pH-metry showed that the drugs in a dose 20 mg significantly inhibit basal acid production. As indicated by electrogastromyography, nifedipine effect on gastric motility depends on its baseline level. The drug displays a moderate normalizing action (modulating effect) on the dominating frequency, amplitude of motor oscillations and overall capacity of gastric biopotentials. Propranolol hydrochloride noticeably lowered initially high frequency of gastric contractions. Due to nifedipine gastric evacuation inhibits and makes more regular. The authors recommend introduction of nifedipine and propranolol hydrochloride in correction of gastric dysfunction in DU patients.

摘要

在90例复发的十二指肠溃疡（DU）患者中评估了单剂量硝苯地平或盐酸普萘洛尔对胃酸分泌和胃动力的影响。胃内pH测定显示，20mg剂量的药物可显著抑制基础胃酸分泌。正如胃电图所示，硝苯地平对胃动力的影响取决于其基线水平。该药物对主导频率、运动振荡幅度和胃生物电位的总体容量具有适度的正常化作用（调节作用）。盐酸普萘洛尔显著降低了最初较高的胃收缩频率。由于硝苯地平，胃排空受到抑制且更加规律。作者建议在DU患者胃功能障碍的纠正中引入硝苯地平与盐酸普萘洛尔。

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