[The clinico-histochemical validation of the differential use of calcium antagonists in gastroduodenal ulcers].

A therapeutic effect of selective calcium antagonists is more evident in older patients with peptide ulcer and under differentiated administration: verapamil is indicated for mediogastric ulcer, nifedipine and diltiazem are better for pyloroantral and duodenal ulcer defect. Responses in ulcer patients may be due to the drugs positive action on ulcer-induced disturbances in the neuromediator processes running in gastroduodenal mucosa.