Forney R, Martz R, Lemberger L, Rodda B
Ann N Y Acad Sci. 1976;281:162-70. doi: 10.1111/j.1749-6632.1976.tb27928.x.
The studies in mice indicated that locomotor activity could be stimulated THC and that this would enhance the effect produced by MAMP. We have previously shown that when 3, 6, or 9 mug/kg THC were administered to young adult males by MJ smoking, a dose-related impairment in standing steadiness (WB) and attentive motor performance (PM) resulted, although DAF and subjective evaluations were insensitive to these treatments. These same testing procedures after d-AMP 5, 10, and 15 mg/70 kg revealed no important performance effect. Systolic blood pressure was elevated with 15 mg/70 kg d-AMP, and subjective detection was positive and dose related. A combination of 25 mug/kg THC delivered by smoking an appropriate MJ cigarette and 10 mg/70 kd d-AMP taken orally produced subjective effects and psychomotor performance decrements not different from those with the MJ alone. The doses used were modest, yet most subjects believed their driving performance, a representative motor and metal skill, would be impaired. This judgment is supported by the laboratory measurements made. It is reasonable that realistically higher doses may not only have adverse psychological and cardiovascular effects but increase an accident potential.
对小鼠的研究表明，四氢大麻酚（THC）可刺激运动活性，且这会增强微小相关分子模式（MAMP）产生的效应。我们之前已经表明，当通过吸食大麻向年轻成年雄性小鼠给予3、6或9微克/千克的THC时，尽管药物渴求（DAF）和主观评估对这些处理不敏感，但会导致站立稳定性（WB）和注意力运动表现（PM）出现剂量相关的损害。在给予5、10和15毫克/70千克的右旋苯丙胺（d-AMP）后，相同的测试程序未显示出重要的行为表现效应。15毫克/70千克的d-AMP会使收缩压升高，且主观检测呈阳性且与剂量相关。通过吸食合适的大麻卷烟给予25微克/千克的THC与口服10毫克/70千克的d-AMP相结合所产生的主观效应和精神运动表现下降与单独使用大麻时并无差异。所使用的剂量适中，但大多数受试者认为他们的驾驶表现（一种典型的运动和心理技能）会受到损害。这一判断得到了实验室测量结果的支持。合理的是，实际更高的剂量可能不仅会产生不良的心理和心血管影响，还会增加事故风险。
