Dalton W S, Martz R, Lemberger L, Rodda B E, Forney R B
Clin Pharmacol Ther. 1976 Mar;19(3):300-9. doi: 10.1002/cpt1976193300.
Experiments investigating the possible interaction of tetrahydrocannabinol (THC) and cannabidiol (CBD), two major components of marihuana, were conducted under controlled laboratory conditions in a double-blind manner. In one study, 15 male volunteers were given placebo or 25 mug/kg of THC together with either placebo or 150 mug/kg of CBD by inhalation of the smoke of a single cigarette. All four treatments were assigned to each subject according to a series of Latin-square designs. CBD significantly attenuated the subjective euphoria of THC. Psychomotor impairment due to THC was not significantly altered by the simultaneous administration of CBD, but a trend indicating a decrease in THC-like effects was observed after the combination. When administered alone CBD was inactive for all the parameters measured. In a second study, 8 male subjects were given CBD (0 or 150 mug/kg) by smoke inhalation 30 min before THC (0 or 25 mug/kg) in a second cigarette. In contrast to the simultaneous administration of both drugs, CBD pretreatment did not alter the effects of THC on the parameters observed.
在可控的实验室条件下，以双盲方式开展了研究大麻两种主要成分四氢大麻酚（THC）和大麻二酚（CBD）可能的相互作用的实验。在一项研究中，15名男性志愿者通过吸入单支香烟烟雾，被给予安慰剂或25微克/千克的THC，同时还被给予安慰剂或150微克/千克的CBD。根据一系列拉丁方设计，将所有四种处理分配给每个受试者。CBD显著减弱了THC引起的主观欣快感。同时给予CBD时，THC导致的精神运动功能损害没有显著改变，但联合使用后观察到一种表明THC样效应降低的趋势。单独给予CBD时，对于所测量的所有参数均无活性。在第二项研究中，8名男性受试者在吸第二支含THC（0或25微克/千克）的香烟前30分钟，通过吸入烟雾给予CBD（0或150微克/千克）。与同时给予两种药物不同，CBD预处理并未改变THC对所观察参数的影响。
