Laursen J B, Boesgaard S, Poulsen H E, Aldershvile J
Medicinsk afdeling B, Rigshospitalet, København.
Ugeskr Laeger. 1994 Sep 26;156(39):5661-6.
The potent vasodilator endothelium derived relaxing factor (EDRF) is released by the vascular endothelium both under basal conditions and upon stimulation by acetylcholine and other endothelium dependent vasodilators. EDRF has been identified as nitric oxide (NO) and provides communication between endothelial and smooth muscle cells in the vascular wall. Injured and/or dysfunctional endothelium as seen in a variety of cardiovascular diseases may result in decreased production of NO leading to unfavorable vasoconstriction and vasospasm whereas its overproduction may cause pathological vasodilation. Understanding the role of nitric oxide in regulation of vascular tone may facilitate novel strategies for prevention and treatment of cardiovascular disorders.
强效血管舒张剂内皮衍生舒张因子（EDRF）在基础条件下以及受到乙酰胆碱和其他内皮依赖性血管舒张剂刺激时，均由血管内皮释放。EDRF已被确认为一氧化氮（NO），它在血管壁的内皮细胞和平滑肌细胞之间起信号传递作用。在多种心血管疾病中可见的内皮损伤和/或功能障碍，可能导致NO生成减少，进而导致不良的血管收缩和血管痉挛，而其过量生成则可能导致病理性血管舒张。了解一氧化氮在调节血管张力中的作用，可能有助于开发预防和治疗心血管疾病的新策略。
