Larner A J, Sturman S G, Hawkins J B, Anderson M
Midland Centre for Neurosurgery and Neurology, Warley, West Midlands, UK.
Acta Neuropathol. 1994;88(2):189-92. doi: 10.1007/BF00294514.
A 65-year-old man developed a painless proximal myopathy 7 years after commencing cyclosporin therapy following a successful cadaveric renal transplant. Muscle histology showed ragged red fibres and biochemical studies suggested mitochondrial dysfunction. The possible pathogenesis of this mitochondrial myopathy, particularly its relationship to cyclosporin-induced hypomagnesaemia, is discussed.
