藏族与汉族健康志愿者之间安替比林和对乙酰氨基酚处置的种族差异。

Ethnic differences in disposition of antipyrine and acetaminophen between Tibetan and Han healthy volunteers.

作者信息

He P, Liu G X, Liu Z H, Sun F Y, Li C Y, Yang Y

机构信息

Tangdu Hospital, 4th Military Medical University, Xi' an.

出版信息

Yao Xue Xue Bao. 1994;29(8):566-9.

PMID:7985514

Abstract

The differences in disposition of antipyrine and acetaminophen between Tibetan and Han healthy volunteers were studied in a randomized crossover design. The half-life of antipyrine was found to be 18.8 +/- 4.89 h in 16 Han and 15.0 +/- 3.02 h in 17 Tibetan (P < 0.05) and the clearance was 1.35 +/- 0.37 L.h-1 in Han and 1.71 +/- 0.44 L.h-1 in Tibetan (P < 0.05). The half-life of acetaminophen was 3.1 +/- 0.86 h in Han and 3.2 +/- 1.12 h in Tibetan (P > 0.05). The experimental results indicate that the disposition of antipyrine between Tibetan and Han healthy volunteers significantly differed, the clearance of antipyrine in Tibetan increased by 20%, but the disposition of acetaminophen between the two ethnic groups showed no difference.

摘要

采用随机交叉设计，研究了藏族和汉族健康志愿者安替比林和对乙酰氨基酚处置情况的差异。结果发现，16名汉族志愿者安替比林的半衰期为18.8±4.89小时，17名藏族志愿者为15.0±3.02小时（P<0.05）；汉族志愿者安替比林的清除率为1.35±0.37L·h-1，藏族志愿者为1.71±0.44L·h-1（P<0.05）。汉族志愿者对乙酰氨基酚的半衰期为3.1±0.86小时，藏族志愿者为3.2±1.12小时（P>0.05）。实验结果表明，藏族和汉族健康志愿者安替比林的处置情况存在显著差异，藏族安替比林的清除率提高了20%，但两个民族对乙酰氨基酚的处置情况无差异。