非洲霍奇金淋巴瘤患者中安替比林的处置情况。
Disposition of antipyrine in African patients with Hodgkin's lymphoma.
作者信息
Juma F D
机构信息
Division of Clinical Pharmacology, College of Health Sciences, University of Nairobi, Kenya.
出版信息
Br J Clin Pharmacol. 1987 Dec;24(6):809-11. doi: 10.1111/j.1365-2125.1987.tb03249.x.
The pharmacokinetics of antipyrine were studied in 12 healthy volunteers and 10 patients of Kenya African origin with Hodgkin's lymphoma. The half-life of antipyrine was 12.2 +/- 1.3 h (mean + s.d.), while the apparent volume of distribution (V) was 0.67 +/- 0.11 l kg-1 (mean +/- s.d.) and the total body clearance was 40.7 +/- 3.2 ml kg-1 h-1 (mean +/- s.d.) in the healthy volunteers. The antipyrine half-life in the patients with advanced Hodgkin's lymphoma was 17.1 +/- 2.7 h (mean +/- s.d.). The apparent volume of distribution was 0.72 +/- 0.14 l kg-1 (mean +/- s.d.) which was larger than in healthy volunteers (P less than 0.05). The total body clearance was 30.3 +/- 9.4 ml kg-1 h-1 (mean + s.d.) and this was reduced compared with that in healthy volunteers (P less than 0.02). After cytotoxic therapy the half-life in the patients with advanced Hodgkin's lymphoma was significantly decreased to 8.3 +/- 1.3 h (mean +/- s.d.) (P less than 0.07), and the apparent volume of distribution was reduced to 0.65 +/- 0.07 l kg-1 (mean +/- s.d.) (P less than 0.05) while the total body clearance increased to 52.8 +/- 5.5 ml kg-1 h-1 (mean +/- s.d.) (P less than 0.01).
在12名健康志愿者和10名患有霍奇金淋巴瘤的肯尼亚裔非洲患者中研究了安替比林的药代动力学。在健康志愿者中，安替比林的半衰期为12.2±1.3小时（均值±标准差），表观分布容积（V）为0.67±0.11升/千克（均值±标准差），全身清除率为40.7±3.2毫升/千克·小时（均值±标准差）。晚期霍奇金淋巴瘤患者的安替比林半衰期为17.1±2.7小时（均值±标准差）。表观分布容积为0.72±0.14升/千克（均值±标准差），大于健康志愿者（P<0.05）。全身清除率为30.3±9.4毫升/千克·小时（均值+标准差），与健康志愿者相比有所降低（P<0.02）。细胞毒性治疗后，晚期霍奇金淋巴瘤患者的半衰期显著降至8.3±1.3小时（均值±标准差）（P<0.07），表观分布容积降至0.65±0.07升/千克（均值±标准差）（P<0.05），而全身清除率增至52.8±5.5毫升/千克·小时（均值±标准差）（P<0.01）。
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