地衣芽孢杆菌M-4中amoebicin m4-A的生物活性
Biological activity of amoebicin m4-A from Bacillus licheniformis M-4.
作者信息
Lebbadi M, Gálvez A, Valdivia E, Martínez-Bueno M, Maqueda M
机构信息
Department of Microbiology, Faculty of Sciences, University of Granada, Spain.
出版信息
Antimicrob Agents Chemother. 1994 Aug;38(8):1820-3. doi: 10.1128/AAC.38.8.1820.
Abstract
Amoebicin m4-A from Bacillus licheniformis M-4 exerts a bactericidal and bacteriolytic action on Bacillus megaterium GR10. Protein, DNA, and RNA synthesis are inhibited, and the membrane electrical potential of this bacterium is depleted by amoebicin. Synthesis of DNA and RNA by Naegleria fowleri HB-1 is also inhibited. Liposomes constructed from L-alpha-phosphatidylcholine become permeable to ions, low-molecular-weight solutes, and high-molecular-weight polymers after treatment with amoebicin.
摘要
地衣芽孢杆菌M-4产生的变形霉素m4-A对巨大芽孢杆菌GR10具有杀菌和溶菌作用。蛋白质、DNA和RNA合成受到抑制，变形霉素使该细菌的膜电位耗尽。福氏耐格里阿米巴HB-1的DNA和RNA合成也受到抑制。用变形霉素处理后，由L-α-磷脂酰胆碱构建的脂质体对离子、低分子量溶质和高分子量聚合物变得具有通透性。
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