Sasako M, Sano T, Katai H, Okajima K, Maruyama K
Gan To Kagaku Ryoho. 1994 Oct;21 Suppl 3:384-94.
Reports of the results of clinical trials on adjuvant chemotherapy for curatively resected gastric cancer were reviewed. All but two trials did not show its efficacy. In spite of this, understanding some results of subset analysis as definite proof, a consensus was achieved in Japan on its efficacy due to lack of proper knowledge of medical statistics among surgeons. Recently it has been recognized that this consensus was groundless and that evaluation of adjuvant chemotherapy should be carried out again. The results of the trial of JCOG, comparing adjuvant chemotherapy versus control (surgery alone) are therefore awaited. For the moment, all clinical trials on adjuvant chemotherapy for curatively resected gastric cancer should have an arm of surgery alone as control.
对已行根治性切除的胃癌辅助化疗临床试验结果的报告进行了回顾。除两项试验外，其他所有试验均未显示出其疗效。尽管如此，由于外科医生对医学统计学缺乏适当了解，将亚组分析的一些结果视为确凿证据，日本在其疗效方面达成了共识。最近人们认识到这一共识毫无根据，应再次对辅助化疗进行评估。因此，正在等待日本临床肿瘤学会（JCOG）比较辅助化疗与对照组（单纯手术）的试验结果。目前，所有针对已行根治性切除的胃癌辅助化疗的临床试验都应以单纯手术作为对照组。
