Lin H C, Wallace S S, Tyler J W, Robbins R L, Thurmon J C, Wolfe D F
Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL 36849-5522.
Aust Vet J. 1994 Aug;71(8):239-42. doi: 10.1111/j.1751-0813.1994.tb03419.x.
The anaesthetic effects of intravenous tiletamine-zolazepam 6.6 mg/kg-ketamine 6.6 mg/kg (TK) and tiletamine-zolazepam 6.6 mg/kg-ketamine 6.6 mg/kg-xylazine 0.11 mg/kg (TKX) were evaluated in six wethers. Heart rate, respiration rate, arterial blood pressure, and the electrocardiogram were monitored during anaesthesia. Analgesia was tested by electrical stimulation in the left flank. Atropine (0.03 mg/kg) was given intramuscularly before induction, but after recording of baseline heart rate and respiratory rate. The duration of analgesia was 28.7 +/- 6.9 min with TK and 82.8 +/- 26.6 min with TKX. Heart rate increased significantly within 5 min after TK or TKX administration. Respiratory rate remained unchanged after TK administration, but increased significantly from 5 to 45 min after TKX administration. Arterial blood pressure decreased significantly at 15 min with TK and 30 min with TKX. Sheep remained recumbent for 201 min with TK and 166 min with TKX. All recovered uneventfully. We conclude that either TK or TKX may be used for anaesthetising sheep.
在六只去势公羊中评估了静脉注射6.6毫克/千克替来他明-唑拉西泮-6.6毫克/千克氯胺酮（TK）和6.6毫克/千克替来他明-唑拉西泮-6.6毫克/千克氯胺酮-0.11毫克/千克赛拉嗪（TKX）的麻醉效果。麻醉期间监测心率、呼吸频率、动脉血压和心电图。通过电刺激左侧胁腹来测试镇痛效果。在诱导前、记录基线心率和呼吸频率后，肌肉注射阿托品（0.03毫克/千克）。TK组的镇痛持续时间为28.7±6.9分钟，TKX组为82.8±26.6分钟。注射TK或TKX后5分钟内心率显著增加。注射TK后呼吸频率保持不变，但注射TKX后5至45分钟呼吸频率显著增加。注射TK后15分钟动脉血压显著下降，注射TKX后30分钟动脉血压显著下降。TK组绵羊躺卧201分钟，TKX组为166分钟。所有绵羊均顺利恢复。我们得出结论，TK或TKX均可用于绵羊麻醉。
