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在不存在双链DNA抗体或（H2A - H2B）复合物抗体的情况下，针对组蛋白（H2A - H2B）-DNA复合物的抗体对硬皮病相关疾病比对狼疮更敏感且更具特异性。

Antibodies to histone (H2A-H2B)-DNA complexes in the absence of antibodies to double-stranded DNA or to (H2A-H2B) complexes are more sensitive and specific for scleroderma-related disorders than for lupus.

作者信息

Wallace D J, Lin H C, Shen G Q, Peter J B

机构信息

Cedars-Sinai Medical Center/UCLA School of Medicine.

出版信息

Arthritis Rheum. 1994 Dec;37(12):1795-7. doi: 10.1002/art.1780371213.

DOI:10.1002/art.1780371213
PMID:7986226
Abstract

OBJECTIVE

To assess the role of antibodies to histones H2A, H2B, and anti-double-stranded DNA which form (H2A-H2B)-DNA complexes in patients with scleroderma-related disorders.

METHODS

Antihistone antibodies were measured, by enzyme immunoassay, in 26 patients with scleroderma-related disorders, 100 patients with systemic lupus erythematosus (SLE), and 24 patients with rheumatoid arthritis.

RESULTS

Antibodies to histone (H2A-H2B)-DNA complex were more commonly seen in patients with scleroderma-related disorders than in those with SLE (P < 0.0001).

CONCLUSION

Scleroderma-related disorders should be included among conditions in which various types of antihistone antibodies are produced. A hypothesis to account for this finding is discussed.

摘要

目的

评估抗组蛋白H2A、H2B抗体以及形成（H2A-H2B）-DNA复合物的抗双链DNA抗体在硬皮病相关疾病患者中的作用。

方法

采用酶免疫分析法检测26例硬皮病相关疾病患者、100例系统性红斑狼疮（SLE）患者和24例类风湿关节炎患者的抗组蛋白抗体。

结果

与SLE患者相比，硬皮病相关疾病患者中更常见抗（H2A-H2B）-DNA复合物组蛋白抗体（P < 0.0001）。

结论

硬皮病相关疾病应被纳入可产生各种抗组蛋白抗体的疾病范畴。文中讨论了对这一发现的一种解释假说。

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