Gioud M, Kaci M A, Monier J C
Arthritis Rheum. 1982 Apr;25(4):407-13. doi: 10.1002/art.1780250408.
Antibodies to total histones and histone fractions H1, H2a-H4, H2b, and H3 were measured in serum samples from 61 patients with systemic lupus erythematosus (SLE), 33 with rheumatoid arthritis, 17 with systemic sclerosis, and 20 with various other diseases by use of a sensitive immunoenzymatic assay. Histone antibodies were present in 52.4% of the SLE samples whereas only 1 of the samples from other diseases was positive (systemic sclerosis). The presence of these antibodies in SLE patients was not associated with any specific clinical manifestations, but was correlated with activity of the disease: 87% (20 of 23) of patients with active SLE, in particular 9 of 9 not yet treated, showed histone antibody whereas only 18% (4 of 22) of samples from patients with inactive SLE were positive. We believe that the measurement of histone antibodies would be a useful addition to the present laboratory parameters (antinuclear and double-stranded DNA antibodies and circulating immune complexes) for the diagnosis and progression of systemic lupus erythematosus, particularly since they seem to appear during or just before the onset of an active phase and tend to be absent during remission.
采用灵敏的免疫酶测定法，检测了61例系统性红斑狼疮（SLE）患者、33例类风湿关节炎患者、17例系统性硬化症患者以及20例患有其他各种疾病患者血清样本中针对总组蛋白和组蛋白组分H1、H2a - H4、H2b和H3的抗体。SLE样本中52.4%存在组蛋白抗体，而其他疾病样本中仅有1例呈阳性（系统性硬化症）。SLE患者体内这些抗体的存在与任何特定临床表现均无关联，但与疾病活动度相关：87%（23例中的20例）活动期SLE患者，尤其是9例未接受治疗的患者，显示有组蛋白抗体，而静止期SLE患者样本中仅有18%（22例中的4例）呈阳性。我们认为，对于系统性红斑狼疮的诊断和病情进展而言，检测组蛋白抗体将是现有实验室指标（抗核抗体、双链DNA抗体和循环免疫复合物）的有益补充，特别是因为它们似乎在疾病活动期开始时或即将开始前出现，而在缓解期往往不存在。
