Erskine R, Murphy P, Langton J A
Queens Medical Centre, Nottingham, U.K.
Alcohol Alcohol. 1994 Jul;29(4):425-31.
The effect of ethyl alcohol on upper airway reflex sensitivity (UARS) has not been previously investigated in humans. Using a technique that we have previously described, intermittent breaths of low concentrations of ammonia vapour were used to measure the effect of ethyl alcohol 0.55-0.66 g/kg on UARS in ten healthy male volunteers. The depression of upper airway reflexes that occurred following ingestion of ethyl alcohol was maximum at 60 min and returned to baseline by 150 min. This dose of ethyl alcohol was insufficient to produce statistically significant depression of UARS. The blood alcohol levels achieved showed a wide range with a mean of 78.9 mg/100 ml (SEM 10.3). Individual subjects who had blood alcohol levels in excess of 100 mg/100 ml displayed much greater depression of UARS. In conclusion, 0.55-0.66 g/kg ethyl alcohol given to healthy male volunteers does not produce significant depression of UARS as measured using an ammonia stimulus technique.
乙醇对人类上气道反射敏感性（UARS）的影响此前尚未进行过研究。采用我们之前描述的技术，让10名健康男性志愿者吸入低浓度氨蒸气的间歇性呼吸，以测量0.55 - 0.66 g/kg乙醇对UARS的影响。摄入乙醇后上气道反射的抑制在60分钟时达到最大，到150分钟时恢复到基线水平。该剂量的乙醇不足以产生具有统计学意义的UARS抑制。所达到的血酒精水平范围很广，平均为78.9 mg/100 ml（标准误10.3）。血酒精水平超过100 mg/100 ml的个体表现出更大程度的UARS抑制。总之，给予健康男性志愿者0.55 - 0.66 g/kg乙醇，使用氨刺激技术测量时，不会产生显著的UARS抑制。
