Willott J F, Carlson S, Chen H
Department of Psychology, Northern Illinois University, DeKalb 60115.
Behav Neurosci. 1994 Aug;108(4):703-13. doi: 10.1037//0735-7044.108.4.703.
Prepulse inhibition was used with C57BL/6J (C57) mice to assess behavioral-perceptual correlates of previously demonstrated physiological changes in the central auditory system associated with age-related hearing loss. Normal-hearing CBA/CaJ (CBA) mice and DBA/2J (DBA) mice, which exhibit extremely rapid hearing loss, were also tested. Tone prepulse stimuli (S1s) were presented 100 ms prior to a startle-evoking noise stimulus (S2), and a decrease in startle amplitude served as the measure of startle modification. As high-frequency hearing declined in C57 mice between 1 and 12 months of age, the efficacy of lower-frequency S1s was significantly enhanced. CBA mice exhibited no age-related changes in startle modification. DBA mice exhibited changes similar to those observed in C57s but at an accelerated rate. The enhanced behavioral saliency of low and middle frequencies in C57 and DBA mice appears to be a consequence of neural plasticity in the central auditory system.
使用C57BL/6J（C57）小鼠的前脉冲抑制来评估与年龄相关性听力损失相关的先前已证明的中枢听觉系统生理变化的行为感知相关性。还测试了听力正常的CBA/CaJ（CBA）小鼠和表现出极快速听力损失的DBA/2J（DBA）小鼠。在引起惊吓的噪声刺激（S2）前100毫秒呈现纯音前脉冲刺激（S1），惊吓幅度的降低作为惊吓调节的指标。随着C57小鼠在1至12个月龄之间高频听力下降，低频S1的效力显著增强。CBA小鼠在惊吓调节方面未表现出与年龄相关的变化。DBA小鼠表现出与C57小鼠相似的变化，但速度更快。C57和DBA小鼠中低频和中频行为显著性的增强似乎是中枢听觉系统神经可塑性的结果。
