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静脉注射血红素预防急性卟啉症发作

Prevention of acute porphyric attacks by intravenous haematin.

作者信息

Lamon J M, Frykholm B C, Bennett M, Tschudy D P

出版信息

Lancet. 1978 Sep 2;2(8088):492-4. doi: 10.1016/s0140-6736(78)92217-1.

DOI:10.1016/s0140-6736(78)92217-1
PMID:79864
Abstract

A thirty-three-year-old female with acute intermittent porphyria (A.I.P.) was having regular attacks of the disease with her menstrual periods. During several of these attacks she received intravenous haematin, which was followed by chemical and clinical remissions. Hormones failed to prevent the regular attacks, which were completely prevented by 200 mg of haematin, given approximately once a week for six months. There were no changes in menstruation. The monthly attacks recurred on withdrawal of haematin.

摘要

一名33岁患有急性间歇性卟啉病(A.I.P.)的女性,其病情在月经期间会定期发作。在几次发作期间,她接受了静脉注射血红素治疗,随后病情出现化学和临床缓解。激素未能预防定期发作,但每周约一次给予200毫克血红素,持续六个月可完全预防发作。月经情况没有变化。停用血红素后,每月发作又会复发。

相似文献

1
Prevention of acute porphyric attacks by intravenous haematin.静脉注射血红素预防急性卟啉症发作
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Danazol administration to females with menses-associated exacerbations of acute intermittent porphyria.对患有月经相关性急性间歇性卟啉病加重期的女性给予达那唑治疗。
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Intravenous heme-albumin in acute intermittent porphyria: evidence for repletion of hepatic hemoproteins and regulatory heme pools.急性间歇性卟啉病中静脉注射血红素白蛋白:补充肝脏血红素蛋白和调节性血红素池的证据
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[Effect of hematin in acute porphyric relapse].[血红素对急性卟啉症复发的影响]
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The effects of haem arginate and haematin upon the allylisopropylacetamide induced experimental porphyria in rats.精氨酸血红素和高铁血红素对烯丙基异丙基乙酰胺诱导的大鼠实验性卟啉症的影响。
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Acute Hepatic Porphyria.急性肝性卟啉症。
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Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic target.血红素加氧酶-1 在急性胰腺炎患者外周血单个核细胞中诱导:一个潜在的治疗靶点。
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Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells.金属卟啉对δ-氨基乙酰丙酸合酶和血红素加氧酶信使核糖核酸水平的不同影响。对培养的鸡胚肝细胞的研究。
J Clin Invest. 1994 Aug;94(2):649-54. doi: 10.1172/JCI117381.
5
Hematin therapy in porphyric attacks.
Klin Wochenschr. 1980 Aug 15;58(16):829-32. doi: 10.1007/BF01491103.
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The "glucose effect" in acute hepatic porphyrias and in experimental porphyria.急性肝卟啉病及实验性卟啉病中的“葡萄糖效应”
Klin Wochenschr. 1981 Jul 1;59(13):727-35. doi: 10.1007/BF01721260.
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Management of attacks of acute porphyria.急性卟啉病发作的管理。
Drugs. 1987 Nov;34(5):604-16. doi: 10.2165/00003495-198734050-00007.