Höhfeld J, Hartl F U
Howard Hughes Medical Institute, New York.
Curr Opin Cell Biol. 1994 Aug;6(4):499-509. doi: 10.1016/0955-0674(94)90068-x.
Significant advances have been made over the past year in analyzing the membrane machineries for the post-translational export of proteins in bacteria and for the import of proteins into mitochondria. Another important development is the identification in mitochondria of homologs of the bacterial heat-shock proteins DnaJ and GrpE, which function together with Hsp70 in membrane translocation and folding of imported proteins. A number of gene products involved in peroxisomal protein uptake have been identified, which are now awaiting biochemical analysis.
在过去一年里，在分析细菌中蛋白质翻译后输出的膜机制以及蛋白质导入线粒体的机制方面取得了重大进展。另一个重要进展是在线粒体中鉴定出细菌热休克蛋白DnaJ和GrpE的同源物，它们与Hsp70一起在导入蛋白质的膜易位和折叠中发挥作用。已经鉴定出一些参与过氧化物酶体蛋白质摄取的基因产物，目前正等待进行生化分析。
