Courtney J M, Lamba N M, Sundaram S, Forbes C D
Bioengineering Unit, University of Strathclyde, Glasgow, UK.
Biomaterials. 1994 Aug;15(10):737-44. doi: 10.1016/0142-9612(94)90026-4.
Consideration of biomaterials for blood-contacting applications should take into account blood-biomaterial interactions, factors influencing the blood response and evaluation procedures. Examination of blood-biomaterial interactions indicates that relevant features are protein adsorption, platelet reactions, intrinsic coagulation, fibrinolytic activity, erythrocytes, leucocytes and complement activation. Factors influencing the blood response to a biomaterial in clinical application are the biomaterial structure, the presence of an antithrombotic agent, the patient status as determined by the disease and drug therapy, and the nature of the application. Evaluation options for biomaterials are clinical, in vivo, ex vivo and in vitro, with ex vivo and in vitro procedures relevant for biomaterial development.
考虑用于血液接触应用的生物材料时，应考虑血液与生物材料的相互作用、影响血液反应的因素以及评估程序。对血液与生物材料相互作用的研究表明，相关特征包括蛋白质吸附、血小板反应、内源性凝血、纤维蛋白溶解活性、红细胞、白细胞和补体激活。在临床应用中，影响生物材料血液反应的因素包括生物材料结构、抗血栓剂的存在、由疾病和药物治疗决定的患者状况以及应用的性质。生物材料的评估选项包括临床、体内、体外和离体评估，其中离体和体外程序与生物材料的开发相关。
