Courtney J M, Sundaram S, Lamba N M, Forbes C D
Bioengineering Unit, University of Strathclyde, Glasgow, Scotland, U.K.
Artif Organs. 1993 Apr;17(4):260-6. doi: 10.1111/j.1525-1594.1993.tb00577.x.
A principal objective of monitoring the blood response in procedures such as hemodialysis and cardiopulmonary bypass is to achieve an enhanced understanding of the relationship between blood component alterations and the biomaterials employed. The aim in a study of blood-biomaterial interactions of deriving a correlation between a characteristic of the biomaterial and a representative parameter of the blood response can be influenced in a clinical situation by antithrombotic agents, multimaterial contact, device utilization, blood condition, drug therapy, and the nature of the application. The selection of parameters representative of the blood response may require a compromise between the advantages of multiparameter assessment and the benefit of measuring a single parameter by a consistent methodology. Representative parameters are protein adsorption, platelet reactions, intrinsic coagulation and the contact activation phase, fibrinolysis, leukocyte alterations, and complement activation. Assessment during clinical application can be approached by consideration of blood response patterns.
在诸如血液透析和体外循环等操作中监测血液反应的一个主要目标是更深入地了解血液成分变化与所使用生物材料之间的关系。在临床情况下，抗血栓药物、多材料接触、设备使用、血液状况、药物治疗以及应用的性质可能会影响研究血液 - 生物材料相互作用以得出生物材料特性与血液反应代表性参数之间相关性的目的。选择代表血液反应的参数可能需要在多参数评估的优势与通过一致方法测量单个参数的益处之间进行权衡。代表性参数包括蛋白质吸附、血小板反应、内源性凝血和接触激活阶段、纤维蛋白溶解、白细胞变化以及补体激活。在临床应用期间的评估可以通过考虑血液反应模式来进行。
