Herman J P, Cullinan W E, Watson S J
Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington 40536-0084.
J Neuroendocrinol. 1994 Aug;6(4):433-42. doi: 10.1111/j.1365-2826.1994.tb00604.x.
The bed nucleus of the stria terminalis (BNST) occupies a central position in pathways regulating hypothalamo-pituitary-adrenocortical (HPA) stress regulation. The potential role of the BNST in tonic neural control of HPA function was assessed by examining effects of selective BNST lesions on expression of ACTH secretagogues in HPA-integrative neurons of the medial parvocellular paraventricular nucleus. Anterior BNST lesions (ABN) involved major portions of the anteromedial, anterolateral, ventromedial, ventrolateral, dorsolateral and juxtacapsular subnuclei. These lesions resulted in significant (30%) decreases in corticotropin-releasing hormone (CRH) mRNA expression across the rostrocaudal extent of the medial parvocellular PVN, with no accompanying changes in basal arginine vasopressin (AVP) mRNA levels. Posterior BNST (PBN) lesions involved large but subtotal damage to the posterior intermediate, posterior medial, posterior lateral and preoptic subnuclei; these lesions resulted in small but significant changes in CRH mRNA and slight increases in number of AVP mRNA-producing parvocellular neurons. PBN effects on CRH mRNA expression were most pronounced at the caudal extent of the medial parvocellular zone, suggesting a topographic input from the posterior BNST to the PVN that is only partially compromised by PBN lesions. Analysis of individual cases revealed a correlation between damage of the anterolateral BNST and decreased CRH mRNA levels, and damage of the posterior intermediate and/or posterior medial BNST and increased CRH mRNA levels. The results suggest differential BNST input into HPA regulation, perhaps reflecting the diversity of limbic input into the BNST region.
终纹床核（BNST）在调节下丘脑 - 垂体 - 肾上腺皮质（HPA）应激反应的通路中占据中心位置。通过检测选择性BNST损伤对内侧小细胞室旁核HPA整合神经元中促肾上腺皮质激素分泌因子表达的影响，评估了BNST在HPA功能的紧张性神经控制中的潜在作用。前BNST损伤（ABN）累及前内侧、前外侧、腹内侧、腹外侧、背外侧和囊周亚核的主要部分。这些损伤导致内侧小细胞室旁核全长范围内促肾上腺皮质激素释放激素（CRH）mRNA表达显著降低（30%），而基础精氨酸加压素（AVP）mRNA水平无伴随变化。后BNST（PBN）损伤对后中间、后内侧、后外侧和视前亚核造成了大面积但不完全的损伤；这些损伤导致CRH mRNA有小但显著的变化，以及产生AVP mRNA的小细胞神经元数量略有增加。PBN对CRH mRNA表达的影响在内侧小细胞区的尾端最为明显，表明从后BNST到室旁核存在一种拓扑学输入，而PBN损伤仅部分破坏了这种输入。对个体病例的分析显示，前外侧BNST损伤与CRH mRNA水平降低之间存在相关性，而后中间和/或后内侧BNST损伤与CRH mRNA水平升高之间存在相关性。结果表明BNST对HPA调节的输入存在差异，这可能反映了边缘系统输入到BNST区域的多样性。
