Sander R
First Medical Department, Municipal Hospital Harlaching, München, Germany.
Gastroenterologist. 1994 Sep;2(3):180-3.
Photodynamic therapy is a new endoscopic procedure for the treatment of malignant or premalignant structure lesions. The underlying principle is selective destruction of tumor cells, which, after accumulating a so called photosensitizer, are irradiated with light of a particular wavelength. Clinical experience to date suggests that, in the field of gastroenterology, endoscopically accessible tumors located within the esophagus, the stomach, or the colorectum of patients with a high surgical risk are particularly suitable for such treatment. If such tumors are limited in size, they can often be treated with curative intent, and remission rates better than 90% can be achieved. Also, palliatively, the tumor mass can be reduced appreciably in a large percentage of patients. The main side effect of this treatment is photosensitization of the skin; perforations and hemorrhage are rare. Improvements in technology and photosensitizers suggest that the procedure will become an established part of the therapeutic concept for gastrointestinal diseases.
光动力疗法是一种用于治疗恶性或癌前结构病变的新型内镜手术。其基本原理是选择性破坏肿瘤细胞，这些细胞在积累一种所谓的光敏剂后，用特定波长的光进行照射。迄今为止的临床经验表明，在胃肠病学领域，手术风险高的患者位于食管、胃或结肠直肠内的内镜可及肿瘤特别适合这种治疗。如果此类肿瘤体积有限，通常可以进行根治性治疗，缓解率可达90%以上。此外，在姑息治疗方面，大部分患者的肿瘤肿块可明显缩小。这种治疗的主要副作用是皮肤光敏反应；穿孔和出血很少见。技术和光敏剂的改进表明，该手术将成为胃肠道疾病治疗理念的既定组成部分。
