具有L1形态且同时存在t(1;19)和t(14;18)染色体易位的B细胞急性淋巴细胞白血病。

B-cell acute lymphoblastic leukemia with L1 morphology and coexistence of t(1;19) and t(14;18) chromosome translocations.

作者信息

Kouides P A, Phatak P D, Wang N, Bennett J M

机构信息

Strong Memorial Hospital, Rochester, New York.

出版信息

Cancer Genet Cytogenet. 1994 Nov;78(1):23-7. doi: 10.1016/0165-4608(94)90041-8.

DOI:10.1016/0165-4608(94)90041-8

PMID:7987801

Abstract

We report a case of adult de novo acute lymphoblastic leukemia (ALL) with unique cytogenetic abnormalities and discrepant morphologic and immunologic features. Morphology was L1 by the French-American-British classification, but flow cytometry was consistent with a mature B-cell phenotype. Cytogenetic analysis showed numerous chromosome abnormalities nonspecific for lymphoid neoplasm except for t(1;19) and t(14;18). The former is characteristic of pre-B-ALL and the latter is characteristic of follicular lymphoma. This is the first report of these two translocations occurring concurrently in ALL.

摘要

我们报告了一例成人原发性急性淋巴细胞白血病（ALL），其具有独特的细胞遗传学异常以及形态学和免疫学特征不一致的情况。根据法国 - 美国 - 英国分类法，形态学表现为L1型，但流式细胞术显示为成熟B细胞表型。细胞遗传学分析显示，除了t(1;19)和t(14;18)外，还有许多对淋巴样肿瘤非特异性的染色体异常。前者是前B - ALL的特征，后者是滤泡性淋巴瘤的特征。这是这两种易位同时发生在ALL中的首例报告。