细胞表现模拟L3型急性淋巴细胞白血病（伯基特样）的急性淋巴细胞白血病患者中的1号与19号染色体易位（t(1;19)）
Translocation t(1;19) in acute lymphoblastic leukemia patients with cytological presentation simulating L3-ALL (Burkitt-like).
作者信息
Lessard M, Fenneteau O, Sainty D, Valensi F, MacIntyre E, Flandrin G
机构信息
Laboratoire Central d'Hématologie, Hôpital Necker-Enfants-Malades, Paris, France.
出版信息
Leuk Lymphoma. 1993 Sep;11(1-2):149-52. doi: 10.3109/10428199309054744.
The t(1;19) in B-lineage ALL is classically associated with a FAB L1/L2 phenotype and the expression of cIg. Recent reports have demonstrated immuno-phenotypic and molecular heterogeneity among cases demonstrating apparently identical karyotypic abnormalities. We report 5 cases of t(1;19) with cytological features resembling an L3 (Burkitt-like) phenotype, suggesting that accurate assessment of these cases requires detailed correlation of cytological, immunological and molecular characteristics.
B淋巴细胞系急性淋巴细胞白血病中的t(1;19)通常与FAB L1/L2表型及胞质免疫球蛋白（cIg）的表达相关。近期报告显示，在具有明显相同核型异常的病例中存在免疫表型和分子异质性。我们报告了5例t(1;19)病例，其细胞学特征类似于L3（伯基特样）表型，这表明对这些病例进行准确评估需要详细关联细胞学、免疫学和分子特征。
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