Epstein M A, Duchowny M, Jayakar P, Resnick T J, Alvarez L A
Comprehensive Epilepsy Center, Miami Children's Hospital, Florida 33155.
Epilepsia. 1994 Nov-Dec;35(6):1204-7. doi: 10.1111/j.1528-1157.1994.tb01790.x.
The relation between hyperventilation (HV)-induced high-amplitude rhythmical slowing (HIHARS) and altered responsiveness without generalized spike and wave activity has not been clearly defined. To test whether altered responsiveness is a nonspecific physiologic response rather than a symptom of generalized epilepsy, we assessed verbal recall ability and motor response testing in 12 healthy nonepileptic children (mean age 9.6 years). Both tasks were administered as a baseline before HV, during HV but before onset of EEG slowing, and during HIHARS. Verbal recall and motor responsiveness remained unchanged during baseline and HV before onset of slowing. During HIHARS, all children exhibited impaired verbal recall (p < 0.005) and 8 of 12 failed to respond to repeated auditory clicks (p < 0.005). Our findings indicate that in a normal setting, responsiveness may be impaired during HV in healthy nonepileptic children.
过度换气（HV）诱发的高振幅节律性慢波（HIHARS）与无广泛性棘波和慢波活动的反应性改变之间的关系尚未明确界定。为了测试反应性改变是一种非特异性生理反应而非全身性癫痫的症状，我们评估了12名健康的非癫痫儿童（平均年龄9.6岁）的言语回忆能力和运动反应测试。两项测试均在HV前作为基线进行，在HV期间但在脑电图减慢发作之前进行，以及在HIHARS期间进行。在减慢发作前的基线和HV期间，言语回忆和运动反应性保持不变。在HIHARS期间，所有儿童均出现言语回忆受损（p<0.005），12名儿童中有8名对重复的听觉滴答声无反应（p<0.005）。我们的研究结果表明，在正常情况下，健康的非癫痫儿童在HV期间反应性可能受损。
