失神癫痫的现状：能引起你的注意吗？
The current state of absence epilepsy: can we have your attention?
机构信息
Assistant Professor of Pediatric and Neurology, Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
出版信息
Epilepsy Curr. 2013 May;13(3):135-40. doi: 10.5698/1535-7511-13.3.135.
Abstract
Absence seizures are common within many different epilepsies and span all the ages. Even though absence seizures were described more than three centuries ago advances associated with its classification, pathophysiology, genetics, treatment, prognosis, and associated co-morbidities continue to be made.
摘要
失神发作在许多不同类型的癫痫中都很常见，并且涵盖了所有年龄段。尽管失神发作在三个多世纪前就已经被描述过，但与它的分类、病理生理学、遗传学、治疗、预后以及相关合并症相关的进展仍在不断取得。
相似文献
1
The current state of absence epilepsy: can we have your attention?失神癫痫的现状：能引起你的注意吗？
Epilepsy Curr. 2013 May;13(3):135-40. doi: 10.5698/1535-7511-13.3.135.
2
Idiopathic focal epilepsies: the "lost tribe".特发性局灶性癫痫：“失落的部落”。
Epileptic Disord. 2016 Sep 1;18(3):252-88. doi: 10.1684/epd.2016.0839.
3
Seizures, syndromes, and etiologies in childhood epilepsy: The International League Against Epilepsy 1981, 1989, and 2017 classifications used in a population-based cohort.儿童癫痫的发作、综合征及病因：基于人群队列研究中使用的国际抗癫痫联盟1981年、1989年及2017年分类法
Epilepsia. 2017 Nov;58(11):1880-1891. doi: 10.1111/epi.13913. Epub 2017 Sep 26.
4
Seizure types, epilepsy syndromes, etiology, and diagnosis.癫痫发作类型、癫痫综合征、病因及诊断。
CNS Spectr. 2001 Sep;6(9):750-5. doi: 10.1017/s1092852900001498.
5
Epilepsy Overview and Revised Classification of Seizures and Epilepsies.癫痫概述及癫痫发作与癫痫的修订分类
Continuum (Minneap Minn). 2019 Apr;25(2):306-321. doi: 10.1212/CON.0000000000000707.
6
The new ILAE report on terminology and concepts for organization of epileptic seizures: a clinician's critical view and contribution.新的 ILAE 关于癫痫发作的术语和概念的报告：临床医生的批判性观点和贡献。
Epilepsia. 2011 Dec;52(12):2155-60. doi: 10.1111/j.1528-1167.2011.03288.x. Epub 2011 Oct 17.
7
[International classification of epileptic seizures, epilepsies, and epileptic syndromes].[癫痫发作、癫痫及癫痫综合征的国际分类]
Rinsho Shinkeigaku. 2004 Nov;44(11):970-4.
8
The phenotype: seizures and epilepsy syndromes.表型：癫痫发作和癫痫综合征
Epilepsy Res Suppl. 1991;4:19-29.
9
Overview: idiopathic generalized epilepsies.概述：特发性全身性癫痫
Epilepsia. 2003;44 Suppl 2:2-6. doi: 10.1046/j.1528-1157.44.s.2.3.x.
10
The absence epilepsies.失神性癫痫
Epilepsia. 1993;34 Suppl 3:S42-8. doi: 10.1111/j.1528-1167.1993.tb06258.x.
引用本文的文献
1
Dysregulation of the Cannabinoid System in Childhood Epilepsy: From Mechanisms to Therapy.儿童癫痫中大麻素系统的失调：从机制到治疗
Int J Mol Sci. 2025 Jun 27;26(13):6234. doi: 10.3390/ijms26136234.
2
The neuronal density in the rostral pole of substantia nigra pars compacta in Wistar Albino rats from Rijswijk rats: A link to spike-wave seizures.来自荷兰里斯维克的Wistar白化大鼠黑质致密部吻侧极的神经元密度：与棘波癫痫发作的联系。
J Biol Methods. 2024 Sep 10;11(3):e99010022. doi: 10.14440/jbm.2024.0027. eCollection 2024.
3
Molecular Mechanisms Underlying the Generation of Absence Seizures: Identification of Potential Targets for Therapeutic Intervention.离子通道突变导致失神发作的分子机制研究：治疗干预靶点的鉴定。
Int J Mol Sci. 2024 Sep 11;25(18):9821. doi: 10.3390/ijms25189821.
4
The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations.代谢型谷氨酸受体 5 在睡眠和觉醒中的作用：关注皮质-丘脑-皮质振荡。
Cells. 2023 Jun 30;12(13):1761. doi: 10.3390/cells12131761.
5
The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities.早期生活环境对失神癫痫及神经精神共病的影响。
IBRO Neurosci Rep. 2022 Nov 9;13:436-468. doi: 10.1016/j.ibneur.2022.10.012. eCollection 2022 Dec.
6
The Effects of Optogenetic Activation of Astrocytes on Spike-and-Wave Discharges in Genetic Absence Epileptic Rats.星形胶质细胞光遗传学激活对遗传性失神癫痫大鼠棘波-慢波放电的影响
Ann Neurosci. 2022 Jan;29(1):53-61. doi: 10.1177/09727531211072423. Epub 2022 Mar 14.
7
Thalamic deep brain stimulation paradigm to reduce consciousness: Cortico-striatal dynamics implicated in mechanisms of consciousness.丘脑深部脑刺激范式降低意识：皮层-纹状体动力学与意识机制有关。
PLoS Comput Biol. 2022 Jul 11;18(7):e1010294. doi: 10.1371/journal.pcbi.1010294. eCollection 2022 Jul.
8
Deletion of Phospholipase C β1 in the Thalamic Reticular Nucleus Induces Absence Seizures.丘脑网状核中磷脂酶Cβ1的缺失诱发失神发作。
Exp Neurobiol. 2022 Apr 30;31(2):116-130. doi: 10.5607/en22007.
9
mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data.代谢型谷氨酸受体 3 作为治疗失神性癫痫的靶点：临床前和人类遗传学数据。
Curr Neuropharmacol. 2023;21(1):105-118. doi: 10.2174/1570159X20666220509160511.
10
Characteristics of Epileptiform Spike-wave Discharges and Chronic Histopathology in Controlled Cortical Impact Model of Sprague-Dawley Rats.斯普拉格-道利大鼠控制皮质撞击模型中癫痫样棘波放电的特征及慢性组织病理学
Neurochem Res. 2022 Dec;47(12):3615-3626. doi: 10.1007/s11064-022-03542-y. Epub 2022 Feb 1.
本文引用的文献
1
Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsies.特发性失神癫痫发病机制中的相关基因和分子机制。
Seizure. 2012 Mar;21(2):79-86. doi: 10.1016/j.seizure.2011.12.002. Epub 2011 Dec 27.
2
Symptoms of anxiety and depression in childhood absence epilepsy.儿童失神性癫痫的焦虑和抑郁症状。
Epilepsia. 2011 Aug;52(8):e70-4. doi: 10.1111/j.1528-1167.2011.03119.x. Epub 2011 Jun 2.
3
A multicenter, randomized, placebo-controlled trial of levetiracetam in children and adolescents with newly diagnosed absence epilepsy.左乙拉西坦治疗新诊断为失神发作的儿童和青少年的多中心、随机、安慰剂对照试验。
Epilepsia. 2011 Apr;52(4):802-9. doi: 10.1111/j.1528-1167.2010.02976.x. Epub 2011 Feb 14.
4
Absence seizures: individual patterns revealed by EEG-fMRI.失神发作：EEG-fMRI 揭示的个体模式。
Epilepsia. 2010 Oct;51(10):2000-10. doi: 10.1111/j.1528-1167.2010.02698.x. Epub 2010 Aug 17.
5
The core network in absence epilepsy. Differences in cortical and thalamic BOLD response.失神发作的核心网络。皮质和丘脑 BOLD 反应的差异。
Neurology. 2010 Sep 7;75(10):904-11. doi: 10.1212/WNL.0b013e3181f11c06. Epub 2010 Aug 11.
6
Do patients with absence epilepsy respond to ketogenic diets?失神癫痫患者对生酮饮食有反应吗？
J Child Neurol. 2011 Feb;26(2):160-5. doi: 10.1177/0883073810376443. Epub 2010 Jul 20.
7
Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures.典型儿童失神发作时的 EEG、fMRI 和行为同步研究。
Epilepsia. 2010 Oct;51(10):2011-22. doi: 10.1111/j.1528-1167.2010.02652.x.
8
Absence epilepsies with widely variable onset are a key feature of familial GLUT1 deficiency.发作起始时间广泛变化的失神癫痫是家族性 GLUT1 缺乏症的一个主要特征。
Neurology. 2010 Aug 3;75(5):432-40. doi: 10.1212/WNL.0b013e3181eb58b4. Epub 2010 Jun 23.
9
Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.乙琥胺、丙戊酸和拉莫三嗪治疗儿童失神癫痫。
N Engl J Med. 2010 Mar 4;362(9):790-9. doi: 10.1056/NEJMoa0902014.
10
Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009.修订的癫痫发作和癫痫分类术语和概念：国际抗癫痫联盟分类和术语委员会 2005-2009 年报告。
Epilepsia. 2010 Apr;51(4):676-85. doi: 10.1111/j.1528-1167.2010.02522.x. Epub 2010 Feb 26.
Zotero 插件