Yamatani M, Konishi T, Murakami M, Okuda T
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Epilepsia. 1994 Nov-Dec;35(6):1199-203. doi: 10.1111/j.1528-1157.1994.tb01789.x.
In 66 children with no neurologic symptoms, we analyzed EEG slowing quantitatively during standardized hyperventilation (HV) activation [respiration rate (RR) of 30/min, threefold increase of VE, and 4-min duration]. Changes in cerebral blood flow (CBF) and velocity were also monitored in right common carotid artery by Doppler ultrasonic method. Decreases in PCO2 and CBF were the fundamental factors producing EEG slowing during HV. The degree of EEG slowing was greater in younger children and well proportional to age with such standardized HV. The decrease in CBF was much greater in younger children at the beginning of HV and may be related to the significant EEG slowing. EEG slowing was not related to the degree of decrease in CBF. The age difference in EEG response to HV in children and adults may be due to the differences in the decrease in the CBF volume and sensitivity of the CNS to the change in CBF.
在66名无神经症状的儿童中，我们在标准化过度通气（HV）激活期间（呼吸频率30次/分钟、分钟通气量增加两倍、持续4分钟）对脑电图减慢进行了定量分析。同时，用多普勒超声法监测右侧颈总动脉的脑血流量（CBF）和血流速度变化。PCO2和CBF的降低是HV期间导致脑电图减慢的基本因素。在这种标准化的HV过程中，年幼儿童脑电图减慢的程度更大，且与年龄密切相关。HV开始时，年幼儿童的CBF下降幅度更大，这可能与显著的脑电图减慢有关。脑电图减慢与CBF下降程度无关。儿童和成人对HV的脑电图反应存在年龄差异，可能是由于CBF容积下降和中枢神经系统对CBF变化的敏感性不同所致。
