Ekeberg O, Klemsdal T O, Kjeldsen S E
Department of Internal Medicine, Ullevaal Hospital, Oslo, Norway.
Eur Heart J. 1994 Aug;15(8):1135-9. doi: 10.1093/oxfordjournals.eurheartj.a060640.
Quality of life was assessed 4-6 months after an acute myocardial infarction in a randomized double-blind study of enalapril versus placebo. Quality of life was evaluated using the Nottingham Health Profile (NHP), the Physical Symptoms Distress Index (PSDI), the Work Performance Scale (WPS) and the Life Satisfaction Index (LSI). The study comprised 36 women (aged 46-85 years, mean 68) and 96 males (aged 39-81 years, mean 62). Quality of life did not differ significantly between patients treated with enalapril versus placebo. The scores were (enalapril vs placebo, mean +/- SE): average NHP 15.4 +/- 2.3 vs 17.1 +/- 2.3; PSDI 9.5 +/- 1.0 vs 10.8 +/- 0.9; WPS 19.8 +/- 2.0 vs 19.4 +/- 1.4; LSI 24.1 +/- 1.0 vs 22.5 +/- 1.4. Men reported a better quality of life than women on most assessments, and non-smokers and ex-smokers better than smokers. Patients with moderate or severe angina pectoris had a worse quality of life measured by PSDI and NHP than patients with minimal or no angina pectoris. Patients with congestive heart failure had a higher PSDI than those without (13.6 +/- 1.7 vs 9.4 +/- 0.7, P < 0.05), while no significant differences were observed in the NHP scores. In conclusion, quality of life was similar in enalapril and placebo-treated patients after an acute myocardial infarction. However, it was reduced in patients with angina pectoris or heart failure and in those who continued smoking.
在一项依那普利与安慰剂的随机双盲研究中，于急性心肌梗死后4 - 6个月评估生活质量。使用诺丁汉健康量表（NHP）、身体症状困扰指数（PSDI）、工作表现量表（WPS）和生活满意度指数（LSI）来评估生活质量。该研究纳入了36名女性（年龄46 - 85岁，平均68岁）和96名男性（年龄39 - 81岁，平均62岁）。接受依那普利治疗的患者与接受安慰剂治疗的患者在生活质量上没有显著差异。得分情况为（依那普利组对比安慰剂组，均值±标准误）：NHP平均得分15.4±2.3对比17.1±2.3；PSDI为9.5±1.0对比10.8±0.9；WPS为19.8±2.0对比19.4±1.4；LSI为24.1±1.0对比22.5±1.4。在大多数评估中，男性报告的生活质量优于女性，非吸烟者和已戒烟者优于吸烟者。中度或重度心绞痛患者通过PSDI和NHP测量的生活质量比轻度或无心绞痛患者更差。充血性心力衰竭患者的PSDI高于无心力衰竭患者（13.6±1.7对比9.4±0.7，P < 0.05），而在NHP得分上未观察到显著差异。总之，急性心肌梗死后接受依那普利和安慰剂治疗的患者生活质量相似。然而，心绞痛或心力衰竭患者以及继续吸烟的患者生活质量降低。
