Schechter M D, Meechan S M
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
Eur J Pharmacol. 1994 Aug 1;260(2-3):133-7. doi: 10.1016/0014-2999(94)90329-8.
CGS 10746B, a dopamine release inhibitor with properties similar to the atypical antipsychotic clozapine, was assessed as to its behavioral properties using spontaneous locomotor activity and the conditioned place preference test. Rats conditioned with interperitoneally administered doses of 1.25, 2.5, 5.0, 10.0, 20.0 or 30.0 mg/kg CGS 10746B showed a conditioned place aversion, whereas only doses of 5.0 mg/kg or greater suppressed locomotor activity. Results are discussed in terms of dopaminergic mediation of conditioned place preference and spontaneous locomotor activity and methodological concerns involved in employing the conditioned place preference test with drugs that produce opposing affective cues.
CGS 10746B是一种多巴胺释放抑制剂，其特性与非典型抗精神病药物氯氮平相似，通过自发运动活动和条件性位置偏爱试验对其行为特性进行了评估。用腹腔注射1.25、2.5、5.0、10.0、20.0或30.0mg/kg CGS 10746B剂量进行条件反射的大鼠表现出条件性位置厌恶，而只有5.0mg/kg或更高剂量能抑制运动活动。根据条件性位置偏爱和自发运动活动的多巴胺能介导作用以及在对产生相反情感线索的药物使用条件性位置偏爱试验时涉及的方法学问题对结果进行了讨论。
