受热轻微诱导的hsc70基因是hsp70基因家族中主要的病毒诱导成员。
The hsc70 gene which is slightly induced by heat is the main virus inducible member of the hsp70 gene family.
作者信息
Sainis I, Angelidis C, Pagoulatos G, Lazaridis I
机构信息
Laboratory of General Biology, Medical School, University of Ioannina, Greece.
出版信息
FEBS Lett. 1994 Dec 5;355(3):282-6. doi: 10.1016/0014-5793(94)01210-5.
PMID:7988690
Abstract
We have found that SV40 infection of CV1 cells induces the synthesis of a 72 kDa protein that upon molecular cloning was shown to be the product of the hsc70 gene. The above gene product was found to be mainly virus inducible, in contrast to the hsp70 gene product which was mainly heat inducible. The two genes were found to be cell cycle regulated in a distinctively different manner.
摘要
我们发现，SV40感染CV1细胞可诱导一种72kDa蛋白质的合成，经分子克隆后显示该蛋白质是hsc70基因的产物。与主要受热诱导的hsp70基因产物相比，上述基因产物主要是病毒诱导型的。发现这两个基因以明显不同的方式受到细胞周期调控。
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