Jagust W J
U.C. Davis Alzheimer's Center, Department of Neurology, University of California, Davis.
J Clin Psychiatry. 1994 Nov;55 Suppl:5-11.
Functional brain imaging using both positron emission tomography and single photon emission computed tomography has been widely applied to the study of dementing diseases. This article reviews the basic approach of the clinician to the problem of dementia, which primarily entails the exclusion of treatable or reversible causes. Structural brain imaging using magnetic resonance imaging or computed tomography to search for reversible structural brain lesions is a key component of this evaluation. Functional imaging may provide clinicians with additional information helpful in establishing the cause of dementia after a reversible illness has been ruled out. Limitations in the data supporting the use of functional images still exist, however, and these images must be interpreted in the context of the overall clinical presentation.
使用正电子发射断层扫描和单光子发射计算机断层扫描的功能性脑成像已广泛应用于痴呆症疾病的研究。本文回顾了临床医生处理痴呆问题的基本方法，主要包括排除可治疗或可逆的病因。使用磁共振成像或计算机断层扫描进行结构性脑成像以寻找可逆性脑结构病变是该评估的关键组成部分。在排除可逆性疾病后，功能性成像可为临床医生提供有助于确定痴呆病因的额外信息。然而，支持使用功能性图像的数据仍存在局限性，并且这些图像必须结合整体临床表现进行解读。
