Leckie B J, Birnie G, Carachi R
MRC Blood Pressure Unit, Western Infirmary, CRC Beatson Laboratories, Glasgow, Scotland.
J Clin Endocrinol Metab. 1994 Dec;79(6):1742-6. doi: 10.1210/jcem.79.6.7989481.
In a prospective study, 25 children with nephroblastoma (Wilms' tumor) had preoperative plasma prorenin and renin concentrations measured. The mean plasma renin and prorenin concentrations in the patients were raised compared with a control group of patients without nephroblastoma. Four children had recurrence of tumor and, in three, this was associated with an increase in plasma prorenin concentration. Nephroblastoma tissue contained immunoreactive renin and renin messenger RNA, and the renin protein was immunologically and biochemically similar to normal human renin. We conclude that prorenin concentrations in plasma are an indicator of nephroblastoma.
在一项前瞻性研究中，对25名肾母细胞瘤（威尔姆斯瘤）患儿术前血浆中的前肾素和肾素浓度进行了测量。与无肾母细胞瘤的对照组患者相比，这些患者的血浆肾素和前肾素平均浓度有所升高。4名患儿出现肿瘤复发，其中3名与血浆前肾素浓度升高有关。肾母细胞瘤组织含有免疫反应性肾素和肾素信使核糖核酸，且肾素蛋白在免疫学和生物化学方面与正常人肾素相似。我们得出结论，血浆中的前肾素浓度是肾母细胞瘤的一个指标。
