Ozcan G, Taner I L, Doğanay T, Iscanoğlu M, Taplamacioğlu B, Gültekin S E, Baloş K
Department of Periodontology, Gazi University School of Dentistry, Ankara, Turkey.
J Nihon Univ Sch Dent. 1994 Sep;36(3):191-8. doi: 10.2334/josnusd1959.36.191.
A study was carried out to compare the effects of subgingival applications of resorbable hydroxypropylmethylcellulose (HPMC) membranes containing 20% chlorhexidine (CHx) and 40% doxycycline (DOXY) placed subgingivally in periodontal pockets greater than 5 mm in depth. Each of 11 patients had at least four pockets. HPMC strips containing CHx and DOXY were inserted into each pocket twice a week for 6 w. One pocket was kept as a control and the other received subgingival scaling and root planing at 0, 1, 3 and 6 w. The microbial flora of 44 pockets from the 11 patients was examined using dark-field microscopy at the baseline and at 1, 3, 6 and 10 w. Clinical parameters including probing depth, crevicular fluid flow, bleeding on probing and gingival shrinkage were also recorded. The CHx and DOXY-administered or root-planed pockets showed marked reduction of both pocket depth and the number of motile organisms. Less bleeding was also observed in CHx and DOXY-inserted pockets.
开展了一项研究，以比较龈下应用含20%洗必泰（CHx）和40%强力霉素（DOXY）的可吸收羟丙基甲基纤维素（HPMC）膜，放置于深度大于5mm的牙周袋龈下的效果。11名患者每人至少有4个牙周袋。含CHx和DOXY的HPMC条带每周插入每个牙周袋两次，共6周。一个牙周袋作为对照，另一个在0、1、3和6周时接受龈下刮治和根面平整。在基线以及1、3、6和10周时，使用暗视野显微镜检查11名患者44个牙周袋的微生物菌群。还记录了包括探诊深度、龈沟液流量、探诊出血和牙龈退缩在内的临床参数。接受CHx和DOXY治疗或根面平整的牙周袋，其袋深度和活动生物体数量均显著减少。在插入CHx和DOXY的牙周袋中也观察到较少的出血。
