The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.

Suppr

超能文献

作者信息

Leeson P D, Iversen L L

机构信息

Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.

出版信息

J Med Chem. 1994 Nov 25;37(24):4053-67. doi: 10.1021/jm00050a001.

DOI:10.1021/jm00050a001

PMID:7990104

Abstract

摘要

相似文献

The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.

J Med Chem. 1994 Nov 25;37(24):4053-67. doi: 10.1021/jm00050a001.

Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.（+）-HA-966和7-氯犬尿氨酸对大鼠培养皮层神经元中N-甲基-D-天冬氨酸受体激动剂反应动力学的影响。

Mol Pharmacol. 1991 May;39(5):666-70.

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.

Bioorg Med Chem. 1997 Dec;5(12):2129-32. doi: 10.1016/s0968-0896(97)00156-9.

Anxiolytic effect of glycine antagonists microinjected into the dorsal periaqueductal grey.

Psychopharmacology (Berl). 1994 Jan;113(3-4):565-9. doi: 10.1007/BF02245241.

The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.NMDA受体甘氨酸位点拮抗剂对大鼠皮质细胞培养物中缺氧诱导的神经变性的影响。

Brain Res. 1990 Oct 29;531(1-2):183-8. doi: 10.1016/0006-8993(90)90772-4.

Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.对大鼠脑N-甲基-D-天冬氨酸受体甘氨酸位点具有更高亲和力和选择性的犬尿氨酸类似物。

Mol Pharmacol. 1992 May;41(5):914-22.

Putative cognition enhancers reverse kynurenic acid antagonism at hippocampal NMDA receptors.假定的认知增强剂可逆转海马N-甲基-D-天冬氨酸受体处犬尿喹啉酸的拮抗作用。

Eur J Pharmacol. 1995 Jan 16;272(2-3):203-9. doi: 10.1016/0014-2999(94)00641-j.

Potentiation of N-methyl-D-aspartate-induced currents by the nootropic drug nefiracetam in rat cortical neurons.促智药奈非西坦对大鼠皮层神经元中N-甲基-D-天冬氨酸诱导电流的增强作用。

J Pharmacol Exp Ther. 2003 Oct;307(1):160-7. doi: 10.1124/jpet.103.050823. Epub 2003 Jun 12.

Structural requirements for the development of potent N-methyl-D-aspartic acid (NMDA) receptor antagonists.

Biochem Pharmacol. 1993 Apr 22;45(8):1547-61. doi: 10.1016/0006-2952(93)90294-7.

The glycine site on the NMDA receptor: structure-activity relationships and possible therapeutic applications.N-甲基-D-天冬氨酸受体上的甘氨酸位点：构效关系及可能的治疗应用。

Curr Med Chem. 1998 Aug;5(4):253-63.

引用本文的文献

Importance of Modulating Kynurenic Acid Metabolism-Approaches for the Treatment of Dementia.调节犬尿喹啉酸代谢的重要性——痴呆症的治疗方法

Biomolecules. 2025 Jan 6;15(1):74. doi: 10.3390/biom15010074.

Discovery of GluN2A subtype-selective -methyl-d-aspartate (NMDA) receptor ligands.谷氨酸N2A亚型选择性 - 甲基 - D - 天冬氨酸（NMDA）受体配体的发现。

Acta Pharm Sin B. 2024 May;14(5):1987-2005. doi: 10.1016/j.apsb.2024.01.004. Epub 2024 Jan 10.

Pharmacophore-Based Screening, Molecular Docking, and Dynamic Simulation of Fungal Metabolites as Inhibitors of Multi-Targets in Neurodegenerative Disorders.基于药效团的筛选、分子对接和真菌代谢产物作为神经退行性疾病多靶点抑制剂的动态模拟。

Biomolecules. 2023 Nov 4;13(11):1613. doi: 10.3390/biom13111613.

Multitargeted Virtual Screening and Molecular Simulation of Natural Product-like Compounds against GSK3β, NMDA-Receptor, and BACE-1 for the Management of Alzheimer's Disease.针对糖原合成酶激酶3β、N-甲基-D-天冬氨酸受体和β-分泌酶1的天然产物类化合物的多靶点虚拟筛选及分子模拟用于阿尔茨海默病的治疗

Pharmaceuticals (Basel). 2023 Apr 20;16(4):622. doi: 10.3390/ph16040622.

Opposite Modulation of the NMDA Receptor by Glycine and S-Ketamine and the Effects on Resting State EEG Gamma Activity: New Insights into the Glutamate Hypothesis of Schizophrenia.甘氨酸和 S-氯胺酮对 NMDA 受体的相反调节作用及对静息状态 EEG 伽马活动的影响：精神分裂症谷氨酸假说的新见解。

Int J Mol Sci. 2023 Jan 18;24(3):1913. doi: 10.3390/ijms24031913.

AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys.AV-101，一种 NMDA 受体甘氨酸位点的前药拮抗剂，可减少 MPTP 猴的左旋多巴诱导的运动障碍。

Cells. 2022 Nov 8;11(22):3530. doi: 10.3390/cells11223530.

Glycine, the smallest amino acid, confers neuroprotection against D-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain.甘氨酸是最小的氨基酸，通过调节小鼠大脑中的 c-Jun N-末端激酶，发挥神经保护作用，对抗 D-半乳糖诱导的神经退行性变和记忆障碍。

J Neuroinflammation. 2020 Oct 15;17(1):303. doi: 10.1186/s12974-020-01989-w.

A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression.一种 N-甲基-D-天冬氨酸受体甘氨酸位点拮抗剂前药 4-氯犬尿氨酸在治疗抵抗性抑郁症中的随机试验。

Int J Neuropsychopharmacol. 2020 Jul 29;23(7):417-425. doi: 10.1093/ijnp/pyaa025.

Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.细胞色素P450侧链裂解酶的抑制通过减少神经性疼痛小鼠模型中脊髓D-丝氨酸的产生来减轻机械性异常性疼痛的发展。

Front Pharmacol. 2019 Dec 6;10:1439. doi: 10.3389/fphar.2019.01439. eCollection 2019.

Does kynurenic acid act on nicotinic receptors? An assessment of the evidence.犬尿酸是否作用于烟碱型受体？证据评估。

J Neurochem. 2020 Mar;152(6):627-649. doi: 10.1111/jnc.14907. Epub 2019 Nov 24.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验