van der Zwan C W, Plantinga A D, Rümke H C, Conyn-van Spaendonck M A
Rijksinstituut voor Volksgezondheid en Milieuhygiëne, Bilthoven.
Ned Tijdschr Geneeskd. 1994 Nov 26;138(48):2390-5.
To estimate the incidence of measles in the Netherlands and assess the effect of vaccination with regard to vaccination status.
Retrospective study.
Data were collected from the Central Bureau for Statistics (CBS), reported cases at the National Health Department (NHD), data from hospitals concerning admissions, morbidity data from the General Practitioner Networks, serological data from virology laboratories and serological data from several other studies.
After introduction of the measles vaccination in 1976, morbidity and reported cases decreased dramatically. Some data suggest that measles in children over 10 years old are reported more frequently. Death caused by measles did not occur after 1988.
The massive vaccination since 1976 resulted in an initial decrease in incidence of measles. The increase in incidence thereafter was probably caused by an increase in, and crowding of vulnerable, older people. No effect on the severity of the complications were seen so far. Surveillance is necessary to follow groups at risk and to take proper preventive measures.
估计荷兰麻疹的发病率，并评估疫苗接种在疫苗接种状况方面的效果。
回顾性研究。
数据收集自中央统计局（CBS）、国家卫生部（NHD）报告的病例、医院的入院数据、全科医生网络的发病率数据、病毒学实验室的血清学数据以及其他几项研究的血清学数据。
1976年引入麻疹疫苗接种后，发病率和报告病例数大幅下降。一些数据表明，10岁以上儿童的麻疹报告更为频繁。1988年后未发生麻疹致死病例。
自1976年以来的大规模疫苗接种导致麻疹发病率最初下降。此后发病率的上升可能是由于易感染的老年人数量增加和人群拥挤所致。目前尚未观察到对并发症严重程度的影响。有必要进行监测，以跟踪高危人群并采取适当的预防措施。
