Santilli F, Narciso N, Bifano D, Villano M, Cerillo A
Institute of Neurosurgery Medical School, Naples, Italy.
Minerva Chir. 1994 Sep;49(9):829-36.
The authors present an epidemiological study of patients who have undergone elective neurosurgery and who have been treated with different types of antibiotics throughout a ten year time span. From the statistic analysis of the different parameters taken into consideration (administering modalities of the short-term and long-term antibiotic, type of sepsis encountered, isolated microorganisms) the authors show, as a result, that the long-term antibiotic prophylaxis is a clearly improper method; the short-term prophylaxis is a correct method the effect of which is, however, still controversial as it does not modify a natural low percentage of infections in elective neurosurgery. The role given to the antibiotic seems much less important compared with the adoption of correct antiseptic measures and of proper nursing.
作者们呈现了一项针对接受择期神经外科手术且在十年时间跨度内接受不同类型抗生素治疗的患者的流行病学研究。通过对所考虑的不同参数(短期和长期抗生素的给药方式、所遇到的败血症类型、分离出的微生物)进行统计分析,结果显示,长期抗生素预防是一种明显不当的方法;短期预防是一种正确的方法,但其效果仍存在争议,因为它并未改变择期神经外科手术中自然存在的低感染率。与采取正确的消毒措施和适当的护理相比,抗生素的作用似乎要小得多。