Adam D
MMW Munch Med Wochenschr. 1978 Feb 10;120(6):163-6.
The Importance of Antibiotic Prophylaxis for Surgery: The current state of the discussion of the benefits and dangers of antibiotic prophylaxis in surgery is critically considered with reference to the literature and our own investigations. Situations where prophylactic administration of antibiotics may be absolutely locigal and where such administration may be without benefit to the patient or even dangerous are commented on. "Shortterm prophylaxis" where antibiotics are given before, during and after the operation for a short period of 24 to 48 hours is particularly discussed. If antibiotics are given they must be effective against the pathogen in question and they must be present in sufficiently high concentrations at the possible sites of infection.
结合文献及我们自己的研究,批判性地考量了当前关于手术中抗生素预防的益处与风险的讨论现状。针对预防性使用抗生素可能完全合理的情况以及这种使用可能对患者无益甚至有害的情况进行了评论。特别讨论了“短期预防”,即在手术前、手术期间及手术后短时间(24至48小时)使用抗生素的情况。如果使用抗生素,它们必须对相关病原体有效,并且在可能的感染部位必须存在足够高的浓度。