Bonetti F, Pea M, Martignoni G, Doglioni C, Zamboni G, Capelli P, Rimondi P, Andrion A
Istituto di Anatomia Patologica, Università di Verona, Italy.
Pathology. 1994 Jul;26(3):230-6. doi: 10.1080/00313029400169561.
We report a comparative study of 3 clear cell tumors of the lung (CCTL) and 3 angiomyolipomas (AML) of the kidney. Morphological analysis shows that the cells of CCTL are identical to the perivascular epithelioid component of AML. Phenotypically they both consistently expressed melanoma-associated antigens recognized by Moabs HMB45 and HMSA-1, while they were negative for HMSA-5. A minority of cells also expressed S-100 protein, vimentin and actin. In addition, one case of CCTL showed mature adipose tissue entrapped in the proliferation, thus suggesting an intermediate form between CCTL and AML. Based on morphological and phenotypical similarities, it is suggested that CCTL and AML belong to the same family of lesions, characterized by the presence of a peculiar muscle cell, expressing different melanoma-associated antigens.
我们报告了一项关于3例肺透明细胞瘤（CCTL）和3例肾血管平滑肌脂肪瘤（AML）的对比研究。形态学分析显示，CCTL的细胞与AML的血管周上皮样成分相同。表型上，它们均持续表达单克隆抗体HMB45和HMSA-1识别的黑色素瘤相关抗原，而对HMSA-5呈阴性。少数细胞还表达S-100蛋白、波形蛋白和肌动蛋白。此外，1例CCTL显示增殖中包绕有成熟脂肪组织，因此提示CCTL与AML之间存在一种中间形式。基于形态学和表型的相似性，提示CCTL和AML属于同一病变家族，其特征为存在一种特殊的肌细胞，表达不同的黑色素瘤相关抗原。
