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皮肤血管平滑肌脂肪瘤——一种应与经典血管平滑肌脂肪瘤相区分的独特实体:对现有病例的全面回顾及基本特征的界定

Cutaneous Angiomyolipoma-A Distinct Entity That Should Be Separated From Classic Angiomyolipoma: Complete Review of Existing Cases and Defining Fundamental Features.

作者信息

Sanchez Natalia Gabriela, Ávila Romay Alfonsina Angelica, Martínez Luna Eduwiges, Padilla Rodríguez Alvaro Lezid

机构信息

DIGIPATH: Digital Pathology Laboratory, Mexico City, Mexico.

Instituto Tecnológico y de Estudios Superiores De Monterrey Campus Ciudad de México, Mexico City, Mexico.

出版信息

JMIR Dermatol. 2022 Sep 27;5(3):e40168. doi: 10.2196/40168.

DOI:10.2196/40168
PMID:37632898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10334929/
Abstract

Cutaneous angiomyolipoma is a rare mesenchymal tumor that is demographically, clinically, and immunohistochemically distinct from its renal and extrarenal counterparts. We present a case of cutaneous angiomyolipoma in the right retroauricular area of a 35-year-old male patient and provide a broad systematic review of the literature and the largest compilation of cutaneous angiomyolipomas reported to date. According to the findings presented in this review, we conclude that cutaneous angiomyolipoma should be completely separated from renal and extrarenal angiomyolipomas and therefore be considered a distinct entity in the classification of skin tumors.

摘要

皮肤血管平滑肌脂肪瘤是一种罕见的间叶组织肿瘤,在人口统计学、临床和免疫组织化学方面与其肾和肾外的同类肿瘤不同。我们报告了一例35岁男性患者右耳后区域的皮肤血管平滑肌脂肪瘤病例,并对文献进行了广泛的系统综述以及对迄今为止报道的皮肤血管平滑肌脂肪瘤进行了最大规模的汇总。根据本综述中的研究结果,我们得出结论,皮肤血管平滑肌脂肪瘤应与肾和肾外血管平滑肌脂肪瘤完全区分开来,因此在皮肤肿瘤分类中应被视为一个独特的实体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4563/10334929/77dd4669f0dd/derma_v5i3e40168_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4563/10334929/a36e43c54625/derma_v5i3e40168_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4563/10334929/52e9e09ca908/derma_v5i3e40168_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4563/10334929/b3fa7985241d/derma_v5i3e40168_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4563/10334929/77dd4669f0dd/derma_v5i3e40168_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4563/10334929/a36e43c54625/derma_v5i3e40168_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4563/10334929/52e9e09ca908/derma_v5i3e40168_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4563/10334929/b3fa7985241d/derma_v5i3e40168_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4563/10334929/77dd4669f0dd/derma_v5i3e40168_fig4.jpg

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Pathology. 2021 Jan;53(1):129-140. doi: 10.1016/j.pathol.2020.08.008. Epub 2020 Oct 31.
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Cutaneous Angiomyolipoma of the Ear: A Rare Diagnostic Challenge.耳部皮肤血管平滑肌脂肪瘤:一项罕见的诊断挑战。
Indian Dermatol Online J. 2020 Mar 9;11(2):226-228. doi: 10.4103/idoj.IDOJ_296_19. eCollection 2020 Mar-Apr.
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Histopathologic characteristics and immunotypes of perivascular epithelioid cell tumors (PEComa).
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Int J Clin Exp Pathol. 2019 Dec 1;12(12):4380-4389. eCollection 2019.
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Renal angiomyolipoma (AML) harboring a missense mutation of with copy-neutral loss of heterozygosity (CN-LOH).携带错义突变 且存在拷贝数中性杂合性丢失(CN-LOH)的肾血管平滑肌脂肪瘤(AML)。
Cancer Biol Ther. 2020 Apr 2;21(4):315-319. doi: 10.1080/15384047.2019.1702406. Epub 2019 Dec 17.
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Cutaneous Angiomyolipoma of the Eyelid in a 2-Year-Old With Tuberous Sclerosis Complex.一名患有结节性硬化症复合体的2岁患儿的眼睑皮肤血管平滑肌脂肪瘤
J Neuroophthalmol. 2021 Mar 1;41(1):e69-e70. doi: 10.1097/WNO.0000000000000863.
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Cutaneous Angiomyolipoma of the Ear: A Case Report and Literature Review.耳部皮肤血管平滑肌脂肪瘤:一例报告及文献复习
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J Belg Soc Radiol. 2018 Apr 20;102(1):41. doi: 10.5334/jbsr.1536.
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