Smit W J, Boquest A L, Geddes J E, Tosolini F A
Department of Medical Microbiology, Austin Hospital, Heidelberg, Victoria.
Pathology. 1994 Jul;26(3):321-4. doi: 10.1080/00313029400169751.
An increase in recovery of Xanthomonas maltophilia from clinical specimens at our institutions prompted, amongst other measures, an investigation of the antibiotic susceptibility patterns of the organism. Fifty-five consecutive first isolates of Xanthomonas maltophilia were obtained and antimicrobial susceptibility tests were carried out by the agar dilution method. Trimethoprim/sulfamethoxazole was the most active antimicrobial agent (94% susceptible), with 71% susceptible to ticarcillin/clavulanic acid, 56% susceptible to ciprofloxacin and 49% susceptible to ceftazidime. Amoxycillin/clavulanic acid and imipenem were inactive (0% susceptible), while aminoglycosides were effective against only 7% of isolates. Potentiation was observed with both the combination of trimethoprim and sulfamethoxazole and the combination of ticarcillin and clavulanic acid. Familiarity with the antibiotic susceptibility pattern of Xanthomonas maltophilia as well as the potential shortcomings of the in vitro susceptibility data are important in the effective clinical management of Xanthomonas maltophilia infections.
在我们机构中，嗜麦芽窄食单胞菌从临床标本中的分离率有所增加，这促使我们采取了一系列措施，其中包括对该菌的抗生素敏感性模式进行调查。我们获取了55株连续的嗜麦芽窄食单胞菌初分离株，并采用琼脂稀释法进行了抗菌药物敏感性试验。甲氧苄啶/磺胺甲恶唑是最有效的抗菌药物（94%敏感），71%对替卡西林/克拉维酸敏感，56%对环丙沙星敏感，49%对头孢他啶敏感。阿莫西林/克拉维酸和亚胺培南无活性（0%敏感），而氨基糖苷类仅对7%的分离株有效。甲氧苄啶和磺胺甲恶唑的组合以及替卡西林和克拉维酸的组合均观察到增效作用。熟悉嗜麦芽窄食单胞菌的抗生素敏感性模式以及体外敏感性数据的潜在缺点，对于嗜麦芽窄食单胞菌感染的有效临床管理至关重要。
