Vilim F S, Cropper E C, Rosen S C, Tenenbaum R, Kupfermann I, Weiss K R
Center for Neurobiology and Behavior, New York State Psychiatric Institute, Columbia University, NY 10032.
Peptides. 1994;15(6):959-69. doi: 10.1016/0196-9781(94)90058-2.
The cholinergic motor neurons for the accessory radula closer (ARC) contain several neuropeptides that affect muscle contractions. In the present study, we have purified and sequenced a sixth ARC neuropeptide, using a combination of high pressure liquid chromatography and bioassays. This neuropeptide, Gly-Leu-Asp-Arg-Tyr-Gly-Phe-Val-Gly-Gly-Leu-amide, has been named buccalin B (BUCb) because it is significantly homologous to the previously characterized neuropeptide buccalin A. BUCb was found to be two-three times more potent than buccalin A in depressing motor neuron induced contractions.
用于辅助齿舌闭合肌（ARC）的胆碱能运动神经元包含几种影响肌肉收缩的神经肽。在本研究中，我们结合高压液相色谱法和生物测定法，纯化并测序了第六种ARC神经肽。这种神经肽，甘氨酸-亮氨酸-天冬氨酸-精氨酸-酪氨酸-甘氨酸-苯丙氨酸-缬氨酸-甘氨酸-甘氨酸-亮氨酸-酰胺，被命名为口侧素B（BUCb），因为它与先前鉴定的神经肽口侧素A具有显著的同源性。研究发现，在抑制运动神经元诱导的收缩方面，BUCb的效力比口侧素A高三倍。
