Romero C, León J, Jara R, González O
Departamento de Obstetricia y Ginecología, Hospital J.J. Aguirre, Universidad de Chile.
Rev Chil Obstet Ginecol. 1993;58(6):465-9.
Gel filtration chromatography in Sephadex G-100, was used to analyse the molecular heterogeneity of prolactin (PRL) in serum from seven hyperprolactinemic women. Chromatographic patterns from samples obtained from four women with hyperprolactinemia and normal menstrual cycles showed a predominance of big-big PRL (79%). In contrast, three women with hyperprolactinemia and amenorrhea presented a chromatographic pattern with predominance of little PRL (69%). The results suggest that the molecular heterogeneity of PRL found is associated with menstrual cycles disorders and hence with ovarian function. Normal ovarian function in hyperprolactinemic patients seems to be associated to increased levels of big-big PRL and altered ovarian function to high level of little PRL.
采用葡聚糖G - 100凝胶过滤色谱法分析了7名高催乳素血症女性血清中催乳素（PRL）的分子异质性。从4名高催乳素血症且月经周期正常的女性获取的样本的色谱图显示，大大PRL占主导（79%）。相比之下，3名高催乳素血症且闭经的女性呈现出以小PRL为主导的色谱图（69%）。结果表明，所发现的PRL分子异质性与月经周期紊乱相关，进而与卵巢功能相关。高催乳素血症患者的正常卵巢功能似乎与大大PRL水平升高有关，而卵巢功能改变则与小PRL水平升高有关。
