Schreiber M, Trojan S
Department of Physiology, 1st Medical Faculty, Charles University, Prague, Czech Republic.
Sb Lek. 1993;94(1):11-7.
In the first part of our experiments we investigated the ascorbic acid content in five areas of the brain in 11 age groups of rats aged 1 to 90 postnatal days. In the area of the olfactory lobe the values vary within the range of 2.9-4.5 mmol/kg fresh weight, with a significant drop on the 21st, 35th and 90th day. In the cerebral cortex the scatter of values was similar with a significant drop on the 21st and 90th day. From the hippocampal area varying values were obtained, the drop on the 5th, 12th, 15th, 21st, 35th and 90th day being significant. The curve of the ascorbic acid content in the area of the vermis cerebelli has the typical shape of a wave. The initial drop is followed by a rise with the maximum on the 18th day. A significant drop was observed on the 5th, 7th and 90th day, a significant rise on the 12th, 15th, 18th and 21st day. In the area of the medulla oblongata the lowest ascorbic acid values in our experiment were recorded. A significant drop was observed on the 5th, 21 st, 35th and 90th day, a significant rise on the 18th day. All significances are referred to one-day old rats. In the second part of our experiments we studied the influence of acute and chronic hypoxia on the ascorbic acid content in liver, adrenal, plasma, cerebrospinal fluid and brain in 18-day-old rats. Due to acute hypoxia a significant decrease in ascorbic acid concentration in the adrenal occurred. Its levels in plasma and cerebrospinal fluid increased significantly compared with controls.(ABSTRACT TRUNCATED AT 250 WORDS)
在我们实验的第一部分，我们研究了出生后1至90天的11个年龄组大鼠大脑五个区域中的抗坏血酸含量。在嗅叶区域，其值在2.9 - 4.5 mmol/kg鲜重范围内变化，在第21天、35天和90天显著下降。在大脑皮层，值的离散情况类似，在第21天和90天显著下降。海马区域获得了不同的值，在第5天、12天、15天、21天、35天和90天下降显著。小脑蚓部区域抗坏血酸含量曲线呈典型的波浪形。最初下降后上升，在第18天达到最大值。在第5天、7天和90天观察到显著下降，在第12天、15天、18天和21天显著上升。在延髓区域记录到了我们实验中最低的抗坏血酸值。在第5天、21天、35天和90天观察到显著下降，在第18天显著上升。所有显著性均参照1日龄大鼠。在我们实验的第二部分，我们研究了急性和慢性缺氧对18日龄大鼠肝脏、肾上腺、血浆、脑脊液和大脑中抗坏血酸含量的影响。由于急性缺氧，肾上腺中抗坏血酸浓度显著降低。与对照组相比，其在血浆和脑脊液中的水平显著升高。（摘要截断于250字）
