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[女性哺乳期脂肪酸谱]

[The spectrum of fatty acids during lactation in women].

作者信息

Mydlilová A, Mourek J, Base J, Smídová L

机构信息

Fakultní Thomayerovy nemocnice, Praha, Czech Republic.

出版信息

Sb Lek. 1993;94(1):25-30.

PMID:7991994
Abstract

The large spectrum of fatty acids (expressed in relative values) was studied in the breast-human milk during the first three weeks of the lactation (3rd, 5th, 10th and 20th day after delivery). All women passed the pregnancy and the delivery without any pathological syndrome and their neonates were found as a healthy and physiological too. No drug dependency was registered. Fatty acids were measured as methyl-esters (FAME) using the method of gas chromatography (1). During the 20 days after delivery and of lactation period, summarising the groups of fatty acid (saturated, monoenoic, PUFA n-3, n-6 and n-9) only few changes could be detected: the increase of the participation of saturated fatty acids of short-medium chain (8:0, 10:0 and 12:0) and of PUFA n-9. Compared with the most administered commercial formula Feminar, the visible differences in the participation of fatty acids were described. Finally: during the lactation we could obtain a large number of significant differences of such individual fatty acids as palmitic acid, arachidonic acid, eicosopentaenoic acid, linoleic acid ect. The possible reasons of such changes during the lactation are discussed and these results are compared with our previous data concerning the fatty acid- spectrum in blood plasma of healthy newborns and preterm or hypoxic infants.

摘要

在哺乳期的前三周(分娩后第3天、第5天、第10天和第20天),对人母乳中的大量脂肪酸(以相对值表示)进行了研究。所有女性均顺利度过妊娠和分娩,无任何病理综合征,其新生儿也被发现健康且生理状况正常。未记录到药物依赖情况。使用气相色谱法(1)将脂肪酸测定为甲酯(FAME)。在分娩后的20天哺乳期内,总结脂肪酸组(饱和脂肪酸、单不饱和脂肪酸、多不饱和脂肪酸n-3、n-6和n-9),仅能检测到少数变化:短中链饱和脂肪酸(8:0、10:0和12:0)以及多不饱和脂肪酸n-9的参与度增加。与最常用的商业配方奶粉Feminar相比,描述了脂肪酸参与度的明显差异。最后:在哺乳期,我们可以获得大量个别脂肪酸(如棕榈酸、花生四烯酸、二十碳五烯酸、亚油酸等)的显著差异。讨论了哺乳期发生此类变化的可能原因,并将这些结果与我们之前关于健康新生儿、早产儿或低氧婴儿血浆中脂肪酸谱的数据进行了比较。

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