Murai T, Mori S, Hosono M, Takeuchi Y, Oohara T, Makino S, Takeda R, Fukushima S
First Department of Pathology, Osaka City University Medical School, Japan.
Teratog Carcinog Mutagen. 1994;14(4):193-201. doi: 10.1002/tcm.1770140406.
Influences of phenacetin (PH) pretreatment on renal pelvic carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were examined in NON/Shi mice of both sexes. Histopathological examination revealed that PH pretreatment enhanced not only the induction of urinary tract carcinoma but also distant metastasis of renal pelvic carcinoma by BBN in male mice. The high incidence of urinary tract carcinoma by PH pretreatment might be due to hydronephrosis and epithelial proliferative lesions enhanced by PH, since a single treatment of PH induced hydronephrosis in all mice and simple hyperplasia in 70-80% of mice used.
在雄性和雌性NON/Shi小鼠中研究了非那西丁（PH）预处理对N-丁基-N-（4-羟基丁基）亚硝胺（BBN）诱导的肾盂癌发生的影响。组织病理学检查显示，PH预处理不仅增强了BBN诱导的雄性小鼠尿路癌的发生，还增强了肾盂癌的远处转移。PH预处理导致尿路癌高发可能是由于PH增强了肾积水和上皮增殖性病变，因为单次给予PH会使所有小鼠发生肾积水，并且使70-80%的所用小鼠出现单纯性增生。
